Mrs. Bierce wears thick bifocal lenses. This phrase clearly indicates that Mrs. Bierce, the subject of the sentence, is a female. I think Mr. Harris is at lunch. In this sentence, Mr. Harris is a male and is the subject of the sentence. When using "Mrs." or "Mr." to address someone, it is common to combine the honorific with a last name to specify the individual being referred to, thus avoiding ambiguity. For instance, at formal social events, addressing someone as "Mrs. Smith" or "Mr. Johnson" clearly identifies the gender of the person being spoken about. Such honorifics help maintain politeness and respect while also aiding listeners or readers in understanding the content of a conversation or written text. It is important to note that in some non-formal settings or different cultural contexts, people may prefer to use full names or other honorifics to convey a higher level of respect or closeness. However, in standard written and verbal communication, "Mrs." and "Mr." remain widely used and effective forms of address. Additionally, as societal attitudes evolve, some individuals may opt for gender-neutral honorifics like "Ms." in place of "Mrs." or "Miss" to accommodate a more diverse range of gender identities and expressions. Despite this, "Mrs." and "Mr." continue to be widely recognized and used, facilitating effective communication in various situations. In summary, "Mrs." and "Mr." in English carry clear gender implications and are appropriate for many occasions. The proper use of these honorifics can better demonstrate respect for others and promote clear, efficient communication.